Author(s): Alok Kumar, Kanchan Singh, Kartik Kumar, Arjun Singh, Alpesh Tripathi, Lakshya Tiwari

Email(s): arjunphar@gmail.com

DOI: 10.52711/2349-2996.2024.00019   

Address: Alok Kumar1, Kanchan Singh1, Kartik Kumar1, Arjun Singh2*, Alpesh Tripathi1, Lakshya Tiwari1
1Department of Pharmacology, School of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer, Rajasthan 305004, India.
2Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2024


ABSTRACT:
Drug resistance poses a significant challenge in cancer therapy, limiting the effectiveness of various treatment modalities and adversely impacting patient outcomes. This review article aims to provide a comprehensive overview of the mechanisms underlying drug resistance in cancer and the associated challenges. We discuss the intrinsic and acquired mechanisms of drug resistance, including genetic alterations, tumor heterogeneity, cellular plasticity, drug efflux pumps, DNA repair mechanisms, and bypass signaling pathways. Additionally, we explore the challenges posed by the tumor microenvironment, cancer stem cells, and the emergence of resistance during treatment. Furthermore, we highlight the strategies employed to overcome drug resistance, including combination therapies, targeted therapies, immunotherapy, nanomedicine, and the potential of precision medicine and biomarker-guided approaches. Finally, we present recent examples and advancements in understanding and overcoming drug resistance in cancer therapy, highlighting the latest research findings and therapeutic approaches.


Cite this article:
Alok Kumar, Kanchan Singh, Kartik Kumar, Arjun Singh, Alpesh Tripathi, Lakshya Tiwari. Drug Resistance in Cancer Therapy: Mechanisms, Challenges and Strategies. Asian Journal of Nursing Education and Research. 2024; 14(1):95-0. doi: 10.52711/2349-2996.2024.00019

Cite(Electronic):
Alok Kumar, Kanchan Singh, Kartik Kumar, Arjun Singh, Alpesh Tripathi, Lakshya Tiwari. Drug Resistance in Cancer Therapy: Mechanisms, Challenges and Strategies. Asian Journal of Nursing Education and Research. 2024; 14(1):95-0. doi: 10.52711/2349-2996.2024.00019   Available on: https://ajner.com/AbstractView.aspx?PID=2024-14-1-19


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