Author(s): Armila Sen, Komal Kumar, Shaheen Khan, Priyanka Pathak, Arjun Singh

Email(s): arjunphar@gmail.com

DOI: 10.52711/2349-2996.2024.00016   

Address: Armila Sen1, Komal Kumar1, Shaheen Khan1, Priyanka Pathak1, Arjun Singh2*
1Department of Pharmacology, School of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer, Rajasthan 305004, India.
2Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2024


ABSTRACT:
Cancer continues to be a global health challenge, with significant morbidity and mortality worldwide. Over the years, substantial progress has been made in understanding the biology of cancer, leading to the development of diverse therapeutic approaches. This article provides a comprehensive overview of current therapies in cancer, including surgery, radiation therapy, chemotherapy, targeted therapy, immunotherapy, and emerging treatment modalities. We discuss the principles, mechanisms of action, clinical applications, and limitations of these therapeutic strategies. Moreover, we highlight the challenges faced in cancer treatment, such as drug resistance, adverse effects, and the need for personalized medicine. Finally, we explore the promising advancements and future directions in cancer therapy, including precision medicine, combination therapies, novel drug delivery systems, and immunotherapeutic strategies. Understanding the current landscape of cancer therapy and exploring innovative approaches will pave the way for improved patient outcomes and a brighter future in the fight against cancer.


Cite this article:
Armila Sen, Komal Kumar, Shaheen Khan, Priyanka Pathak, Arjun Singh. Current Therapy in Cancer: Advances, Challenges, and Future Directions. Asian Journal of Nursing Education and Research. 2024; 14(1):77-4. doi: 10.52711/2349-2996.2024.00016

Cite(Electronic):
Armila Sen, Komal Kumar, Shaheen Khan, Priyanka Pathak, Arjun Singh. Current Therapy in Cancer: Advances, Challenges, and Future Directions. Asian Journal of Nursing Education and Research. 2024; 14(1):77-4. doi: 10.52711/2349-2996.2024.00016   Available on: https://ajner.com/AbstractView.aspx?PID=2024-14-1-16


REFERENCES:
1.    Pragya Pathak, Rajender Mahal, Adarsh Kohli, Vinod Nimbran. A Quasi Experimental Study to Evaluate the Effectiveness of Progressive Muscle Relaxation on Anxiety and Depression among Hospitalised Cancer Patients receiving Radiotherapy. Asian J. Nur. Edu. and Research. 2013; 3(1): 42-46.
2.    Nirmala V., Athahari Begu, Anuradha. Effectiveness of Video Assisted Teaching Programme on Prevention of Oral Cancer among Tobacco Chewers. Asian J. Nur. Edu. and Research. 2012; 2(2): 83-86.
3.    Arjun Patidar, S.C. Shivhare, Umesh Ateneriya, Sonu Choudhary. A Comprehensive Review on Breast Cancer. Asian J. Nur. Edu. and Research. 2012; 2(1): 28-32.
4.    R. Adlin Pon Joy. Effect of Foot Reflexology on Pain among Cancer Patients in Oncology Ward, Sri Ramakrishna Hospital, Coimbatore. Asian J. Nur. Edu. and Research. 2011; 1(4): 107-108.
5.    Gautam, Y., Dwivedi, S., Srivastava, A., Hamidullah, Singh, A., Chanda, D., Singh, J., Rai, S., Konwar, R., Negi, A.S.  2-(3′,4′-Dimethoxybenzylidene) tetralone induces anti-breast cancer activity through microtubule stabilization and activation of reactive oxygen species. RSC Adv.  2016; 6: 33369–33379.
6.    Hamid, A.A., Hasanain, M., Singh, A., Bhukya, B., Omprakash, Vasudev, P.G., Sarkar, J., Chanda, D., Khan, F., Aiyelaagbe, O.O., Negi, A.S. Synthesis of novel anticancer agents through opening of spiroacetal ring of diosgenin. Steroids. 2014; 87: 108–118.
7.    Hamid, A.A., Kaushal, T., Ashraf, R., Singh, A., Chand Gupta, A., Prakash, O., Sarkar, J., Chanda, D., Bawankule, D.U., Khan, F., Shanker, K., Aiyelaagbe, O.O., Negi, A.S. (22β,25R)-3β-Hydroxy-spirost-5-en-7-iminoxy-heptanoic acid exhibits anti-prostate cancer activity through caspase pathway. Steroids. 2017; 119: 43–52.
8.    Jain, S., Singh, A., Khare, P., Chanda, D., Mishra, D., Shanker, K., Karak, T. Toxicity assessment of Bacopa monnieri L. grown in biochar amended extremely acidic coal mine spoils. Ecological Engineering. 2017; 108: 211–219.
9.    Khwaja, S., Fatima, K., Hasanain, M., Behera, C., Kour, A., Singh, A., Luqman, S., Sarkar, J., Chanda, D., Shanker, K., Gupta, A.K., Mondhe, D.M., Negi, A.S. Antiproliferative efficacy of curcumin mimics through microtubule destabilization. European Journal of Medicinal Chemistry. 2018; 151: 51–61.
10.    Kumar, B.S., Ravi, K., Verma, A.K., Fatima, K., Hasanain, M., Singh, A., Sarkar, J., Luqman, S., Chanda, D., Negi, A.S. Synthesis of pharmacologically important naphthoquinones and anticancer activity of 2-benzyllawsone through DNA topoisomerase-II inhibition. Bioorganic and Medicinal Chemistry. 2017; 25: 1364–1373.
11.    Mishra, D., Jyotshna, Singh, A., Chanda, D., Shanker, K., Khare, P. Potential of di-aldehyde cellulose for sustained release of oxytetracycline: A pharmacokinetic study. International Journal of Biological Macromolecules. 2019; 136: 97–105.
12.    Sathish Kumar, B., Kumar, A., Singh, J., Hasanain, M., Singh, A., Fatima, K., Yadav, D.K., Shukla, V., Luqman, S., Khan, F., Chanda, D., Sarkar, J., Konwar, R., Dwivedi, A., Negi, A.S. Synthesis of 2-alkoxy and 2-benzyloxy analogues of estradiol as anti-breast cancer agents through microtubule stabilization. European Journal of Medicinal Chemistry. 2014; 86: 740–751.
13.    Sathish Kumar, B., Singh, Aastha, Kumar, A., Singh, J., Hasanain, M., Singh, Arjun, Masood, N., Yadav, D.K., Konwar, R., Mitra, K., Sarkar, J., Luqman, S., Pal, A., Khan, F., Chanda, D., Negi, A.S. Synthesis of neolignans as microtubule stabilisers. Bioorganic and Medicinal Chemistry. 2014; 22: 1342–1354.
14.    Singh, A., Mohanty, I., Singh, J., Rattan, S. BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ROCK signaling and nonadrenergic noncholinergic relaxation via increased NO release. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2020; 318: G23–G33.
15.    Singh, A., Rattan, S. BDNF rescues aging-associated internal anal sphincter dysfunction. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2021; 321: G87–G97.
16.    Singh, A., Singh, J., Rattan, S. Evidence for the presence and release of BDNF in the neuronal and non‐neuronal structures of the internal anal sphincter. Neurogastroenterology and Motility. 2021.
17.    Singh, Aastha, Fatima, K., Singh, Arjun, Behl, A., Mintoo, M.J., Hasanain, M., Ashraf, R., Luqman, S., Shanker, K., Mondhe, D.M., Sarkar, J., Chanda, D., Negi, A.S. Anticancer activity and toxicity profiles of 2-benzylidene indanone lead molecule. European Journal of Pharmaceutical Sciences. 2015; 76: 57–67.
18.    Singh, Aastha, Fatima, K., Srivastava, A., Khwaja, S., Priya, D., Singh, Arjun, Mahajan, G., Alam, S., Saxena, A.K., Mondhe, D.M., Luqman, S., Chanda, D., Khan, F., Negi, A.S.  Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer. Chem Biol Drug Des. 2016; 88: 625–634.
19.    Manmohan, S., Arjun, S., Khan, S. P., Eram, S., and Sachan, N. K. Green chemistry potential for past, present and future perspectives. International Research Journal of Pharmacy. 2012; 3: 31-36.
20.    Singh, A., R. Sharma, K. M. Anand, S. P. Khan, and N. K. Sachan. Food-drug interaction. International Journal of Pharmaceutical and Chemical Science. 2012; 1(1): 264-279.
21.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2022; 12(4): 349-0. doi: 10.52711/2231-5713.2022.00055
22.    Devender Paswan, Urmila Pande, Alka Singh, Divya Sharma, Shivani Kumar, Arjun Singh. Epidemiology, Genomic Organization, and Life Cycle of SARS CoV-2. Asian Journal of Nursing Education and Research. 2023; 13(2): 141-4.
23.    Arjun Singh, Rupendra Kumar, Sachin Sharma. Natural products and Hypertension: Scope and role in Antihypertensive Therapy. Asian Journal of Nursing Education and Research. 2023; 13(2): 162-6.
24.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2012; 12(4):349-0.
25.    Arjun Singh, Rupendra Kumar. An Overview on Ethnopharmacological, Phytochemical, and Clinical Significance of Selected Dietary Polyphenols. Asian Journal of Research in Chemistry. 2023; 16(1): 8-2.
26.    Arjun Singh. Plant-based Isoquinoline Alkaloids: A Chemical and Pharmacological Profile of Some Important Leads. Asian Journal of Research in Chemistry. 2023; 16(1): 43-8.
27.    Singh, A., Chanda, D., and Negi, A. S. Antihypertensive activity of Diethyl-4, 4'-dihydroxy-8, 3'-neolign-7, 7'-dien-9, 9'-dionate through increase in intracellular cGMP level and blockade of calcium channels (VDCC) and opening of potassium channel and in vivo models (SHRs and L-NAME induced hypertension). In Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology). 2018;  PO1-2. Japanese Pharmacological Society.
28.    Sampoornam. W. Stress and Quality of Life among Breast Cancer Patients. Asian J. Nur. Edu. and Research. 2014; 4(3): 325-327.
29.    Ravi Barot, T. Sivabalan. A study to evaluate the Quality of life in Head and Neck Cancer Patients admitted in Pravara Rural Hospital, Loni (Bk). Asian J. Nur. Edu. and Research. 2013; 3(1): 21-24.
30.    Jeenath Justin Doss K. Effectiveness of Foot Massage on Level of Pain among Patients with Cancer. Asian J. Nur. Edu. and Research. 2014; 4(2): 228-231.
31.    SedighehIranmanesh, Ala Shamsi. The Relationship between Type of Cancer and Parent's Psychosocial Risks. Asian J. Nur. Edu. and Research. 2014; 4(4): 495-501.
32.    Jasmine Kaur. An Exploratory Study to Assess the Quality of Life among Cancer Patients of District Bathinda, Punjab. Asian J. Nur. Edu. and Research. 2015; 5(1): 18-22.
33.    Anusha D Souza, Babu D, Gireesh GR. Assess Level of Risk of Cervical Cancer among Women in selected Community Area, Mangalore. Asian J. Nur. Edu. and Research. 2014; 4(4): 461-468.
34.    A Case Study on Ovarian Cancer – Palliative Perspective. Asian J. Nur. Edu. and Research. 2015; 5(3): 446-448.
35.    S. Shakila, S. Rajasankar, N. Kokilavani. A study to assess the Knowledge regarding Cervical Cancer among Women. Asian J. Nur. Edu. and Research. 2015; 5(3): 307-310.
36.    J. Vijaya Raja Kumar, Uma M. Effectiveness of Acupressure on improving the Quality of Sleep among Cancer Patients. Asian J. Nur. Edu. and Research. 2015; 5(4): 513-517.
37.    J. Jaslina Gnanarani, Latha Venkatesan. The Palliative Care Needs, Quality of Life and Coping Strategies among Oncology Patients and End Stage Organ Disease. Asian J. Nur. Edu. and Research. 2016; 6(3): 371-376.

Recomonded Articles:

Author(s): Poonam Sheoran, Sulakshana Chand, Sukhwinder Kaur

DOI:         Access: Open Access Read More

Author(s): Aksa Peter, Angel Maria P. T, Aniet Bijo, Ani Rose Thomas1 Anju Mol Varghese, Annie Thomas, Vineeth Joseph

DOI: 10.5958/2349-2996.2017.00099.4         Access: Open Access Read More

Author(s): Ramya K.R, Vineetha R.

DOI:         Access: Open Access Read More

Author(s): Neethu Jose

DOI: 10.5958/2349-2996.2015.00058.0         Access: Open Access Read More

Author(s): Naik Sumati Alias Pallavi Devidas1, Theresa Leonilda Mendonca

DOI: 10.5958/2349-2996.2017.00075.1         Access: Open Access Read More

Author(s): Anto Merlin Soniya S, Reeta Jebakumari Solomon, Shini

DOI: 10.5958/2349-2996.2019.00040.5         Access: Open Access Read More

Author(s): Amol Bhagwat Kanade, Shubhangi Sarwan, Pradnya Said, Suvarna Kadam, Gokul Dhakne, Pramod Gore

DOI: 10.5958/2349-2996.2021.00045.8         Access: Open Access Read More

Asian Journal of Nursing Education and Research (AJNER) is an international, peer-reviewed journal devoted to nursing sciences....... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2349-2996 

Popular Articles


Recent Articles




Tags